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Veronica Pinamonti

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Open access Aug 2026

Engineering editopes through programmable RNA editing toward tumor neoantigen generation.

Short Precise-Encodable ADAR Recruiting (SPEAR) gRNAs are developed that harness endogenous ADAR1 to direct precise adenosine-to-inosine (A-to-I) editing at selected transcript sites and demonstrate the generation of immunogenic neoepitopes through RNA editing at the transcript level, termed editopes.

R. Pecori, Beatrice Casati, Rona Merdler-Rabinowicz et al. · 0 citations

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