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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Verena Bopp

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Open access Aug 2026

Targeting CDC42 with CASIN Reprograms Cell-Type-Specific Transcriptomes and MAPK-Driven Transcription Factor Networks in the Aging Brain

Background Parkinson’s disease (PD) is driven by α-synuclein (α-syn) aggregation and affects vulnerable dopaminergic and GABAergic neurons, and its incidence rises dramatically with age. In our α-syn mouse model, motor impairment required both α syn oligomers and the aging milieu, and pharmacological inhibition of the...

Jaehyun LeeBae, Verena Bopp, Bettina Möhrle et al. · 0 citations
Open access Sep 2026

Spreading alpha-synuclein oligomers trigger astrocyte/microglial changes and astrocyte-glutamatergic neuron system dysfunction in an age-related manner

A model in which α-syn oligomer spreading, amplified by aging, simultaneously disrupts the astrocyte–glutamatergic neuron axis and drives microglia into a senescent DAM-like state is proposed, and candidate gene sets for both processes are provided for further investigation of glial dysfunction in PD.

Jaehyun LeeBae, Verena Bopp, Alicia Goreth et al. · 0 citations

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