Open access
Aug 2026
TLSB-09 TARGETED P16 KNOCKOUT CONFERS AN IMMUNOSUPPRESSIVE MICROENVIRONMENT IN PRECLINICAL MODELS OF TRIPLE NEGATIVE BREAST CANCER BRAIN METASTASIS
A role for p16 loss as a candidate functional driver of ICI resistance associated with 9p21 loss in TNBC-BM is suggested and warrant further investigation given the need to nominate biomarkers for ICI response to inform patient care.
Varun Sasisekharan, Naema Nayyar, C. Torrini et al.
· Neuro-Oncology Advances · 0 citations