Vanessa E. Wall

HRAS promotes mutant NRAS-driven transformation with codon and allele specificity

It is found that the requirement for wild-type RAS to support mutant NRAS–driven transformation correlated with codon-specific differences in GTP hydrolysis, which defines the signaling partnership between mutant NRAS and wild-type HRAS as a targetable vulnerability and provides a biochemical blueprint for dual RAS inh...