Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors
Histone deacetylase 8 (HDAC8) has emerged as a promising therapeutic target due to its role in epigenetic regulation. In this study, novel non-hydroxamate-based quinoline analogues were designed and explored as HDAC8-selective inhibitors that exhibit nanomolar HDAC8 enzymatic inhibition. Notably, compounds BHC-10 and B...