Residue-Level Energetic Analysis of Transient Misfolding in the Whirlin PDZ Tandem Reveals a Possible Connection to an AlphaFold-Predicted Alternative Topology
Multidomain proteins may populate transient misfolded states that compete with productive folding, but the molecular determinants of these intermediates remain poorly understood. Using the tandem PDZ domains of the scaffolding protein whirlin, in which a misfolded intermediate accumulates only when both domains are den...
Valeria Pennacchietti, Mariana Di Felice, Julian Toso et al.
· International Journal of Mol... · 0 citations