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DrugMR is a Nextflow pipeline that runs cis-Mendelian randomisation, colocalisation, SMR-HEIDI with bulk and/or single-cell QTLs, three-trait colocalisation and a phenome-wide screen for adverse effects and repurposing, applied to schizophrenia with brain pQTLs.
A brain maintenance mechanism that supports the brain's ability to resist to changes in neuronal integrity is suggested, suggesting a brain maintenance mechanism that supports the brain's ability to resist to changes in neuronal integrity in Alzheimer's disease.
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
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