Author

V. Yan

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Open access Oct 2026

Spatiotemporal heterologous vaccination relies on type I interferons at priming to enhance mucosal immunity.

Parenteral vaccines against respiratory viruses poorly block infection and transmission due to suboptimal induction of mucosal immunity. In contrast, hybrid immunity and heterologous-route immunization regimens generate protective mucosal and systemic immunity. Herein, we examine how chronological order in heterologous...

Matthew J. Wiest, Gabriel Laghlali, Julianne d'Acunzo et al. · EMBO Molecular Medicine · 0 citations

Open access Sep 2026

Evaluation of new adjuvants in enhancing the immune response to a candidate of Severe Fever with Thrombocytopenia Syndrome Virus vaccine

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease caused by the tick-borne bunyavirus SFTSV. SFTSV is primarily transmitted by Haemaphysalis longicornis ticks and can cause a hemorrhagic fever-like illness characterized by high fever, thrombocytopenia, leukopenia, and multiorgan failure...

J. Levican, Natalia Ferressini Gerpe, Seok-Chan Park et al. · bioRxiv · 0 citations

Open access Aug 2026

Adjuvanted mucosal vaccination enhances protection and prevents influenza virus transmission in the guinea pig model

Influenza virus infects the respiratory mucosa, highlighting the importance of mucosal immunity for early protection and transmission control. Here, we evaluated whether intranasal (IN) vaccination with recombinant trimeric hemagglutinin protein from A/Michigan/45/2015 (triHA) formulated with a combined mucosal adjuvan...

V. Yan, Seok-Chan Park, Matthew J. Wiest et al. · bioRxiv · 0 citations