Open access
Aug 2026
Early-life stress-induced gut dysbiosis is ameliorated by nicotinamide treatment
Early life stress (ELS) in the form of adverse experiences in childhood results in multiple psycho-physiological pathologies during adulthood and accelerates aging. Such pathologies are recently observed to be alleviated upon nicotinamide treatment in a maternal separation model of ELS. We report a nicotinamide-driven amelioration of gut dysbiosis in middle-aged rodents with a history of neonatal maternal separation.
Stuti Srivastav, Pratik R. Chaudhari, Shital Suryavanshi et al.
· bioRxiv · 0 citations