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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

V. Sabapathy

h-index 10 View on Semantic Scholar

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Oct 2026

Programmed cell death protein 1 (PD-1) regulates metabolic activity of regulatory T cells in ischemia-induced acute kidney injury.

It is demonstrated that PD-1 knockout mice have worse renal function after IRI when compared to wild-type mice, and the metabolic vulnerability of PD-1-deficient Tregs is revealed, highlighting the critical role of PD-1 in Treg-mediated nephroprotection.

Oliver B. Pelletier, Murat Dogan, Christopher G. O'Neill et al. · 0 citations
Open access Jul 2026

Notch signaling pathway mediates anti-inflammatory effects of vagus nerve stimulation during lipopolysaccharide-induced acute kidney injury.

Using a mouse model of lipopolysaccharide (LPS)-induced AKI, it is found that CAP activation by vagus nerve stimulation (VNS) enhanced Notch2 signaling in macrophages, mitigating inflammation in the spleen and tissue damage in the kidneys, thereby protecting the kidneys.

Shuhei Kuwabara, Hiro Inoue, W. Nash et al. · 0 citations

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