Author

V. Milam

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#protein folding Open access Oct 2026

The MODNAP benchmark set for modeling ribose-based modified nucleic acid and nucleic acid–protein complexes: a case study with AlphaFold 3

MODNAP is established as a resource for evaluating and improving structure prediction methods for modified nucleic acids by benchmarking AlphaFold 3 on 1039 nucleic acid and nucleic acid–protein complex structures spanning a range of nucleotide modifications, tertiary folds, and biological functions.

Jie-Min Fu, V. Milam, Andrew C. McShan · Nucleic Acids Research · 0 citations

Open access Sep 2026

CompELS vs SELEX: Comparative Aptamer Discovery Integrating Rational Libraries and Enzymatic Elution

Aptamers are oligonucleotides that fold into structures with target-binding activity comparable to antibodies, yet their discovery remains laborious and inconsistent. Traditional Systematic Evolution of Ligands by Exponential Enrichment (SELEX) screening often relies on randomized sequence libraries, repeated amplifica...

Steven Ochoa, V. Milam · ACS nano medicine · 0 citations