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Open access Sep 2026

Quinoline-Aminothiophenol Derivative Triggers Pronounced Mitochondrial Dysfunction and Cell Death in Leishmania infantum.

Current therapies for visceral leishmaniasis (VL) remain limited, underscoring the need for new therapeutic alternatives. Here, we investigated the activity of a novel quinoline analogue containing 2-aminothiophenol, designated TQCl, against Leishmania infantum and sought to provide initial insights into its mode of ac...

Stephane França Ribeiro, Wander Luiz Alves Amorim, Bruno Vicente et al. · 0 citations
Open access Oct 2026

New Organic Compounds Against Scedosporium and Mucorales: Antifungal Activity and Mechanisms of Cell Wall and Membrane Disruption

The emergence of infections caused by Scedosporium/Lomentospora and Mucorales species poses a major clinical challenge due to their intrinsic resistance to multiple antifungal drugs and the limited number of therapeutic options available. In this study, we evaluated the antifungal activity of synthetic organic compound...

R. Rollin-Pinheiro, Yuri de Castro Almeida, Mariana Ingrid Dutra da Silva Xisto et al. · 0 citations

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