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Open access Oct 2026

Metabolic Signatures of Resistance to Mycobacterium Tuberculosis Infection: Insights from a Multi-Country Plasma Metabolomics Study

Background: Tuberculosis (TB) remains the leading infectious disease cause of mortality worldwide. A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) remain TST/IGRA-negative despite sustained exposure, termed "TB resisters". The biological mechanisms underlying this resistance remain poorly understood...

C. Liu, J. M. Collins, M. F. Gyorfy et al. · 0 citations
Review Open access Sep 2026

Duration of effectiveness of tuberculosis preventive treatment across various tuberculosis burden settings: a systematic review and individual-participant meta-analysis.

BACKGROUND Millions of individuals at risk of tuberculosis are given tuberculosis preventive treatment (TPT) annually. However, questions remain regarding the duration of protection from TPT and potential variability across populations and settings with disparate tuberculosis risk. We aimed to assess the effect of TPT...

Lauren Linde, J. I. Campbell, C. Horsburgh et al. · 1 citation

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