Author

V. Malysheva

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Open access Oct 2026

Human FACT complex coordinates cohesin and transcription on chromatin

The spatial organisation of eukaryotic genomes is critical for coordinating DNA-dependent processes such as transcription and replication. Cohesin contributes to this organisation by extruding chromatin loops; however, how cohesin achieves processive translocation along nucleosome-dense chromatin in vivo remains poorly...

Jonay García-Luis, A. Canela, V. Malysheva et al. · bioRxiv · 0 citations

#machine learning Preprint Sep 2026

Beyond Gradient Flow: Identifiability and Recovery from Distribution Snapshots

Inferring dynamics from snapshots of evolving distributions is fundamentally underdetermined: the Fokker-Planck equation constrains the drift $F$ only through its score-weighted divergence $\nabla\cdot F+F\cdot\nabla\log\rho$, leaving a $\rho$-solenoidal gauge invisible to any single-time constraint. Time-indexed trans...

Nam Nguyen, V. Malysheva · 0 citations