V. M. Tesmer

A direct protein bridge connects the ds and ds-ss junction telomeric DNA segments in C. elegans

The six-protein shelterin complex safeguards mammalian chromosome ends; however, its intricate protein-protein and protein-DNA interactions complicate biochemical dissection. The C. elegans DNA binding TEBP-1/2 (also known as DTN-1/2) and POT-1 proteins directly interact, offering a simplified system to dissect chromos...