Author

V. M. Heine

3 papers indexed here

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Open access Oct 2026

Glia-enriched human brain organoids for studying developmental alterations in leukodystrophies

Leukodystrophies (LKD) comprise mostly inherited white matter disorders whose developmental origins and underlying pathomechanisms remain poorly understood. Progress has been limited by restricted access to human primary tissue and by the inability of animal models to fully recapitulate human neurodevelopment. Human in...

Elisabeth Mangiameli, Li-Za M. L. Kok, Clarissa Rosato et al. · bioRxiv · 0 citations

Open access Aug 2026

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

During neural development, cells generate and respond to mechanical forces within their microenvironment while they migrate and differentiate. These forces are central to the development of the human brain, as they are transduced into intracellular signals that regulate key neurobiological processes and may be involved...

P. V. van Altena, Lucia Castillo Ransanz, R. Guis et al. · Advances in Materials · 0 citations

Open access Sep 2026

From consent to participatory governance: The need for multi-stakeholder alignment in iPSC-based drug repurposing.

Induced pluripotent stem cells (iPSCs) are increasingly used as disease models to accelerate drug repurposing, especially for rare diseases. While ethical and regulatory issues in iPSC research have been widely discussed, little is known about how these challenges are addressed in practice. To provide insights into the...

Esther A. M. Bührman, A. Geille, M. Cornel et al. · Stem Cell Reports · 0 citations