Reduction of forebrain interneurons alters cellular organization and cortical neurogenesis in a mouse model of X-linked intellectual disability
Arx is an X-linked transcription factor that is expressed in inhibitory neurons within the ganglionic eminences during embryogenesis. In humans, ARX variants are one of the leading causes of X-linked intellectual disabilities (XLID) and related syndromes. While most often studied in males, recent evidence indicates tha...