Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60-80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two...
E. Uffelmann, D. Wightman, S. Bahrami et al.· Nature· 0 citations
Multimodal integration of cognitive, neuroimaging, and polygenic data in the MHS-RWD tool yields strong discrimination for both early diagnosis of dementia and AD differential diagnosis, which could support etiologically informed dementia decisions in real-world settings, with potential utility in primary care.
T. T. Filiz, V. Fominykh, K. Persson et al.· medRxiv· 0 citations
Recent large-scale studies have enabled new knowledge about genetic underpinnings of morphological and electrophysiological alterations of the retina. Variation in retinal traits, often of neurodevelopmental origin, have been linked to major psychiatric disorders (MPDs). Here, we investigate the genetic overlap between...
P. Jahołkowski, N. Parker, I. Sveen et al.· medRxiv· 0 citations
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