Neuroendocrine Disruptors (NEDs) are increasingly recognized as a significant environmental and public health concern, particularly in low-resource settings where environmental contamination and inadequate waste management may increase human exposure. NEDs include a heterogeneous group of exogenous chemicals capable of...
Andrea Faa, M. Lastretti, Monica Piras et al.· Healthcare in Low-resource S...· 0 citations
Key mechanisms identified include Nrf2/HO-1-driven oxidative stress and neuronal apoptosis, disruption of calcium signalling and synaptic plasticity via CREB phosphorylation deficits, epigenetic suppression of brain-derived neurotrophic factor via promoter hypermethylation, interference with thyroid hormone bioavailabi...
M. Lastretti, Andrea Faa, Monica Piras et al.· Environments· 0 citations
Obesity arises from intertwined and reciprocal diet-microbiome-host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle-related lifecourse dynamics from birth to older age, examines how...
I. Kalafati, D. Krongauz, Alice Bosco et al.· Obesity Reviews· 0 citations
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