V. Copeland

Adverse effect of left ventricular hypertrophy in women with heart failure

Left ventricular hypertrophy is a hallmark of adverse remodeling in heart failure (HF), yet commonly used echocardiographic measures provide limited insight into sex-specific risk. Interventricular septal (IVS) thickness is routinely measured, but its independent prognostic value and potential sex-related differe...

History of hypertension is associated with improved survival in patients with nonischemic etiology of heart failure and reduced ejection fraction.

Chronic kidney disease in metabolic syndrome and heart failure: elevated risk, underutilized therapies, and missed opportunities for improved outcomes

Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic disorder involving heart disease, kidney disease, diabetes, and obesity. Chronic kidney disease (CKD) is highly prevalent in this advanced phenotype, increases mortality risk, and complicates optimal therapy selection. We evaluated mortality, dialysis r...

Calcium Channel Blockers are Safe and Beneficial in Patients with Heart Failure and Advanced Chronic Kidney Disease.

In patients with heart failure and advanced chronic kidney disease, CCBs use was associated with improved survival, supporting their potential role as a safe adjunctive therapy for blood pressure control in this high-risk population.

Point-of-care echocardiography screening for hypertrophic cardiomyopathy using automated deep-learning analysis

Abstract Aims Hypertrophic cardiomyopathy (HCM) remains underdiagnosed due to limited access to expert imaging. We developed and validated a deep-learning (DL)-based echocardiographic model adaptable to point-of-care ultrasound (POCUS) for scalable HCM screening. Methods and results We retrospectively analysed 134 956...

Frailty Attenuates the Prognostic Value of Multimorbidity in Heart Failure - Insights From the Largest Tertiary Center in the Middle East.

Frailty fundamentally attenuates risk in HF, while multimorbidity stratifies prognosis only when physiological reserve is preserved, while multimorbidity stratifies prognosis only when physiological reserve is preserved.