V. Bryja

SorCS2 controls Wnt signaling homeostasis during neurodevelopment by regulating Ror2 activity and trafficking

Molecular mechanisms behind the functional (non)redundancy of CK1 paralogs in the Wnt pathway

The findings resolve prior contradictions by clarifying context-dependent CK1 roles, identifying mechanistic determinants navigating CK1α and CK1ε to different substrates, and defining the limitations of these affinity-based subcellular distributions that become apparent especially in the physical absence of the physio...