Author

V. Bouratzis

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Review Open access Sep 2026

Revising NHE‐1: From Cardiac Homeostasis to Heart Failure and Future Drug Development

NHE‐1 is a Na+/H+ exchanger that receives phosphorylation signals, binds calmodulin and responds to neurohormonal input from angiotensin II, endothelin‐1, and adrenergic pathways. In cardiac myocytes, NHE‐1 maintains pH homeostasis and couples to Na+/Ca2+ exchange and mitochondrial ion handling. During heart disease su...

V. Bouratzis, Nikoleta Douskou, Nikolaos P. Tzavellas et al. · Cell Biochemistry and Functi... · 0 citations

Open access Sep 2026

LDL-C Target Attainment and Treatment Gaps Six Months After Acute Coronary Syndrome: insights from the CALLINICUS-Hellas registry.

BACKGROUND Low-density lipoprotein cholesterol (LDL-C) reduction is the cornerstone of secondary prevention after acute coronary syndrome (ACS). Despite potent lipid-lowering therapies (LLTs), a therapeutic gap persists. We aimed to evaluate LDL-C target attainment according to the 2019 ESC/EAS guidelines, identify pre...

L. Rallidis, D. Tsamoulis, D. Benetou et al. · Hellenic Journal of Cardiolo... · 0 citations

Preprint Jul 2026

EchoRisk: A Multicentre Echocardiography Dataset and Benchmark for Cardio-Oncology

B baseline performance is established using an R(2+1)D video backbone with LSTM aggregation trained from Kinetics-400 pretrained weights, demonstrating strong discriminative performance for cardiac functional assessment and LV dysfunction classification, while early cardiotoxicity prediction from a single pre-therapy v...

G. Kalliatakis, G. Karanasiou, Georgios C. Manikis et al. · 1 citation