Uttam Prasad Panigrahy

Safinamide dual molecular mechanisms: sodium channel and glutamate modulation as a translational rationale for neuropathic pain – A narrative review

Abstract Introduction Neuropathic pain is a chronic and debilitating condition characterized by maladaptive changes in peripheral and central nervous system pathways. It is driven by abnormal neuronal excitability and excitatory neurotransmission. Among the key contributors are voltage-gated sodium channels (VGSCs) and...

Circular RNAs at the crossroads of oxidative stress: novel targets for precision therapeutics

Comprehensive Review on AQbD-Enabled Latest Advancements of Bioanalysis Using Hyphenated Techniques in Drug Product Development

This review provides a thorough investigation into the design and validation of bioanalytical techniques utilizing the AQbD framework, in accordance with ICH rules that delineate GLP and controlled bioanalysis.