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Author

Ute Distler

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Open access Aug 2026

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis

Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralization remain unclear. Here, we study the parasite’s H...

Louis Sarrazin, Melissa R. Rosenthal, J. Kloehn et al. · 0 citations
Open access Sep 2026

Integrative multi-omics analysis reveals lipid/metabolite dysregulation and temporal decoupling in disease progression

Key metabolic control points (ceramide accumulation, arginine flux diversion, autophagy–lipid cross-talk, NAD⁺ salvage timing) were identified, highlighting potential targets for stage-specific therapeutic or nutritional interventions.

Uchenna Alex Anyaegbunam, V. ten Cate, Katrin Bauer et al. · 0 citations
Open access Aug 2026

A map of human protein-protein interaction embeddings for functional discovery

A protein’s function depends not just on its own structure and localization, but also on the interactions with its partners. Many proteins are therefore better described by a set of partner-dependent roles than by a single annotation. Yet most approaches to the functional interpretation of protein-protein interactions...

Mert Cihan, Ute Distler, M. Andrade-Navarro · 0 citations

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