Sep 2026
Adenovirus early proteins E1A and E3-19K reveal separable regulatory states of the ER stress sensor IRE1a.
The unfolded protein response (UPR) controls cellular homeostasis and virus infections. It is canonically initiated by dissociation of ER chaperone BiP/GRP78 from lumenal domains of transmembrane sensor proteins, including the central UPR sensor inositol-requiring enzyme 1 alpha (IRE1a). This results in IRE1a activatio...
Debkanya Sengupta, S. Srivastava, Fedor Bezrukov et al.
· Molecular Biology of the Cel... · 0 citations