Biophysical considerations for designing viruses, lipid nanoparticles and virus-like particles for CRISPR-based genome editing.
This review examines how biophysical properties of viral vectors, lipid nanoparticles, and hybrid virus-like particles influence editor delivery performance and explores how the notion of carrier systems shifts in diseased states like solid tumour cancers, autoimmune psoriasis of the skin, and the autosomal monogenic c...