Author

Ulrike B. S. Hedrich

2 papers indexed here

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Review Open access Oct 2026

KCNA2-Associated Hereditary Spastic Paraplegia: Clinical Characteristics and Rationale for Targeted Treatment.

BACKGROUND A single recurrent variant, NM_004974.4(KCNA2):c.881G>A:p.(Arg294His), causes hereditary spastic paraplegia (HSP) through a unique variant-specific mechanism. Data from paralogous variants suggest that this may be a druggable mechanism. OBJECTIVE The objective of this work is to give an overview of the cli...

C. Boßelmann, M. Vyhnálek, Zuzana Blichová et al. · Movement Disorders · 0 citations

Open access Sep 2026

Scorpion toxin peptide BMK86-P1 achieves mutation-reversible inhibition of KCNA2 at the cost of reduced efficacy in heteromers and murine neurons

Solid-phase synthesized the KV1.1.2 specific scorpion toxin peptide BMK86-P1 and oxidized it with modest efficacy, highlighting the limits of peptide synthesis together with the need for testing specific compounds on complex systems.

Elisabeth M. M. Brand, Lorenz Over, Hubert Kalbacher et al. · bioRxiv · 0 citations