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Review Open access Aug 2026

Long-Acting Injectable Antipsychotics in Schizophrenia and Comorbid Substance Use Disorder: A Systematic Review of the Literature

Highlights What are the main findings? Nine studies involving 2062 patients with schizophrenia and comorbid substance use disorder (SUD) were included, with follow-up periods ranging from 6 months to 3 years. Several studies reported favorable clinical outcomes with long-acting injectable (LAI) antipsychotics, but the...

Matteo Lupi, A. Carano, Eros Rossi et al. · 0 citations
Open access Sep 2026

From real-world experience to precision prescribing of antidepressants: a machine-learning analysis of clinicians' treatment choices.

Antidepressant prescribing in major depressive disorder is guided by evidence-based recommendations, but real-world decisions often rely on clinical judgment, previous experience, and case-based reasoning. This study examined whether psychiatrists' routine prescribing decisions could be used to identify practice-ground...

Francesco Calabrò, Claudio Caiazza, U. Albert et al. · 0 citations
Open access Sep 2026

Predicting early psychiatric readmission among people with major depressive disorder: A machine learning analysis from the prospective multicentre DEEP READ study.

These findings suggest that standard clinical variables may hold predictive value for early readmission in MDD, however, external validation, assessment of model calibration, and clinical utility are needed prior to clinical implementation.

F. Bartoli, Mario Luciano, C. Crocamo et al. · 0 citations
Open access Aug 2026

Differential associations of inflammatory-metabolic markers with depressive symptom dimensions: Towards a clinical phenotyping of immune-metabolic depression.

BACKGROUND Depression is increasingly conceptualized as a biologically heterogeneous condition, with immune-inflammatory and metabolic dysregulation implicated in specific symptom dimensions rather than overall depressive severity. However, it remains unclear whether different combinations of inflammatory and metabolic...

M. Di Nicola, M. Pepe, A. Aguglia et al. · 0 citations

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