Author

U. Olsson

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Open access Sep 2026

DNAJB6b — a complete amyloid inhibitor

It is shown that JB6 binds to Aβ42 fibrils with high affinity and that this binding can quantitatively explain the observed elongation inhibition, offering a mechanistic link between chaperone–fibril binding and amyloid suppression.

Andreas Carlsson, U. Olsson, S. Linse · bioRxiv · 0 citations

Open access Aug 2026

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation

The authors study the impact of DNAJB6b on tau fibril formation, showing that it delays tau aggregation by co-assembling with small tau aggregates and by binding to mature fibrils, reducing their ability to catalyze further fibril growth.

Andreas Carlsson, Emil Axell, Johan Wallerstein et al. · Communications Chemistry · 1 citation · ⚡1