Solid tumors evade immunotherapy because of immunosuppressive microenvironments that limit immune cell persistence and function. Although interleukin-12 (IL-12) potently activates antitumor immunity, its clinical use has been constrained by systemic toxicity. Here we engineered a CAR natural killer (NK) cell platform t...
Mubin Tarannum, K. Dinh, Mila Stanojevic et al.· Cancer Discovery· 0 citations
Endometrial cancers classified as having no specific molecular profile (NSMP) represent the most prevalent molecular subtype of the disease. In this review, we summarize the immunogenomic landscape and phenotypic features of NSMP endometrial cancer and discuss current and emerging therapeutic strategies, including endo...
Tarik Silk, U. Matulonis, Panagiotis A. Konstantinopoulos· Gynecologic Oncology· 0 citations
It is shown that decreased activity of multiple RB function-predictive transcriptional signatures, which suggests that RB is functional, corresponds to response to the CDK4/6i.
Zelei Yang, U. Bhattarai, Martin Hayes et al.· Clinical Cancer Research· 0 citations
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