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Author

U. Grewal

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7 papers indexed here

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Open access Sep 2026

MetScore and classical–basal subtype intersect to define chemotherapy response and tumor microenvironment architecture in pancreatic ductal adenocarcinoma

Background Transcriptomic heterogeneity in pancreatic ductal adenocarcinoma (PDAC) is conventionally modeled along a single classical–basal axis, but this framework incompletely explains clinical behavior. We hypothesized that MetScore, a single-sample measure of metastatic colonization potential, defines a complementa...

Raymond E. Preston, Hong-Yun Huang, Margaret A. Hall et al. · 0 citations
Editorial Open access Aug 2026

Patient‐reported outcomes and targeted therapeutic escalation in NRG Oncology/RTOG 1010: When intensification fails to translate to improved outcomes

In NRG Oncology/RTOG 1010, HER2‐targeted escalation did not improve survival or patient‐reported outcomes in localized esophageal adenocarcinoma. The study illustrates that biologic plausibility and metastatic success do not guarantee benefit in the curative‐intent setting and emphasizes the need for rigorous, patient‐...

T. J. Brown, N. Hornstein, U. Grewal et al. · 0 citations
Open access Aug 2026

RAF/MEK clamp inhibition with avutometinib and cetuximab in RAF1 S257L–mutated, anti-EGFR–refractory metastatic colorectal cancer in Gaucher’s disease

Abstract RAF1 alterations are rare in metastatic colorectal cancer (mCRC), occurring in roughly 0.5% of cases, and lack established treatment guidance. We present a patient with RAF1 S257L–mutated, RAS wild-type mCRC and concurrent type 1 Gaucher disease, whose baseline cytopenias precluded standard chemotherapy and cl...

A. Rose, Alix Rosenberg, U. Grewal et al. · 0 citations
Open access Sep 2026

Care delivery among patients with early-onset versus average-onset cholangiocarcinoma: a nationwide retrospective analysis

Background Cholangiocarcinoma (CCA) is an aggressive biliary malignancy with increasing incidence and poor prognosis. Although traditionally considered a disease of older adults, early-onset CCA (EOCCA; age <50 years) may represent a clinically distinct subgroup. Data evaluating diagnostic and treatment trajectories in...

U. Grewal, A. Nottke, B. Loeffler et al. · 0 citations
Sep 2026

Abstract A028: Metastatic potential defines an orthogonal axis of transcriptomic heterogeneity that predicts chemotherapy response and tumor microenvironment architecture in pancreatic ductal adenocarcinoma

Metastatic cell state is established as an independent and clinically actionable dimension of PDAC biology that complements classical–basal subtype classification and will inform chemotherapy backbone choice in KRAS inhibitor trials, as well as treatment following progression on KRAS inhibitor monotherapy.

Raymond E. Preston, Hong-Yun Huang, Margaret A. Hall et al. · 0 citations
Sep 2026

Comparative Analysis of Characteristics and Outcomes of Patients with Early-Onset Versus Average-Onset Small Bowel Neuroendocrine Tumors.

EO-SBNETs represent a rising and clinically distinct subgroup characterized by similar presentation and treatment but relatively favorable long-term outcomes compared with AO-SBNETs, suggesting potential biological differences warranting further investigation.

Matthew T. Gao, Rishi R. Patel, Jason Semprini et al. · 0 citations
Open access Aug 2026

Age-stratified mutation patterns in early-onset colorectal cancer reveal distinct molecular features and therapeutic implications

Differences in mutations of key genes including a lower prevalence of APC mutations and increased SMAD4 mutations in younger individuals provides further supporting evidence that early-onset CRC may represent a distinct biological subtype of CRC.

L. Liu, A. Rose, A. Samaddar et al. · 0 citations

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