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U. GaykeA

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Open access Oct 2026

Optimization of a Self-MicroemulsifyingDrug Delivery System (SMEDDS) of Ziprasidone using a Quality by Design (QbD) Approach

Ziprasidone hydrochloride is a poorly water-soluble atypical antipsychotic exhibiting dissolution-limited oral absorption. The present study aimed to develop and optimize a Self-Microemulsifying Drug Delivery System (SMEDDS) of Ziprasidone using a Quality by Design (QbD) approach to enhance its solubility and dissoluti...

U. GaykeA, V. Pawar, S. ShindeV et al. · 0 citations
Open access Oct 2026

Development and In Vitro Evaluation of a pH-Responsive Hydrogel for Colon-Targeted Delivery of a Glucocorticoid

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, requires effective local drug delivery to the colon while minimizing systemic corticosteroid exposure. Budesonide is a potent glucocorticoid with high local anti-inflammatory activity; however, its poor aqueous solubility and limited si...

U. GaykeA, Salunke Prajkta, Kotame R. NPatil S. D. Shinde V. S et al. · 0 citations

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