Author

U. A. Çevi̇k

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Oct 2026

Synthesis, in silico study and cytotoxic evaluation of new benzimidazole derivatives as potential aromatase inhibitors.

AIMS A new series of benzimidazole derivatives (4a-4p) was designed, synthesized, and evaluated as potential aromatase inhibitors with anticancer activity. MATERIALS AND METHODS The anticancer effects of the compounds were evaluated using the MCF-7 cell line. Derivatives that showed activity were subjected to an arom...

A. Işık, Nour El-huda Daoud, Kezban Uçar Çiftçi et al. · Future Medicinal Chemistry · 0 citations

Open access Oct 2026

Design and Synthesis of New Thiazole Derivatives for Alzheimer’s Disease Therapy as a Potential Cholinesterase Inhibitor; Toxicity Prediction and Molecular Docking Studies and Biological Evaluation

In this study, thiazole derivatives 13–23 were synthesized as novel cholinesterase inhibitors. Their structures were elucidated using 1H-NMR, 13C-NMR, and elemental analysis techniques. The binding positions and efficiencies of the designed compounds on the enzyme were investigated through molecular docking studies, an...

Mesut Işık, Gresa Halimi Syla, Abdüllatif Karakaya et al. · Molecules · 0 citations

Open access Jul 2026

Design, Synthesis, In Silico ADME, Toxicity Prediction and Molecular Docking Studies of Benzimidazole-Oxadiazole Derivatives for α-Glucosidase and Aldose Reductase Pathways as Potent Anti-Diabetic Agents

Overall, the newly synthesized compounds demonstrated pronounced AR inhibitory activity and notable α-GLY inhibition and may therefore be considered potential candidates for further investigation as anti-diabetic agents.

Mesut Işık, Abdüllatif Karakaya, U. A. Çevi̇k et al. · Molecules · 0 citations