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Tyler J. Rutherford

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Review Open access Aug 2026

Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron

The tetrahedral DNA nanostructure (TDN) has emerged as a premier, highly programmable framework for targeted drug delivery and diagnostics. This review provides a definitive, chemistry‐first design guide for TDN engineering, systematically structured across three translational tiers. First, we examine foundational deri...

Tyler J. Rutherford, C. Wilds · 0 citations

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