Dynamics of ERK/MAPK and NF-κB signaling pathways in macrophages with repeated stimulation by lipopolysaccharide at a single cell level
ERK and NF-κB are key regulators of macrophage responses to external stimuli, resulting in the secretion of inflammatory cytokines and exhibiting antimicrobial functions. Macrophage tolerance is a dampened response to repeated lipopolysaccharide (LPS) stimulation and is linked to immunosuppression in patients with seps...