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The results identify RvPeti as a founding member of a previously uncharacterized family of metalloprotease family conserved across bacteria and eukaryotes and provide a structural framework for investigating the physiological and evolutionary roles of this widespread protein family.
Human cytochrome P450 2C9 (CYP2C9) is a hepatic microsomal enzyme involved in the oxidative metabolism of clinically important drugs, but the structural organization of its oligomeric assemblies outside crystallographic packing environments remains poorly understood. Here, we report the cryo-EM structure of human CYP2C...
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