Author

Troy Nations

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Open access Oct 2026

DNA2 nuclease inactivation induces DNA damage through a potential protein trapping mechanism.

It is found that expression of DNA2 nuclease-dead alleles exert dominant effects on fitness and DNA damage repair that are dependent on its helicase and RPA binding activities, suggesting a protein trapping mechanism, perhaps associated with extensive helicase activity.

Katherine E. Baillie, Si-Jie Zhang, Jian Qin et al. · DNA Repair · 0 citations