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Tristan Friet

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Open access Aug 2026

Structural insights into the exosite-mediated activation of Factor IX by Factor XIa using cryo-EM.

The first cryo-EM structures of FXIa in complex with its substrate, FIX, and activated FIX (FIXaβ) define the full FXIa:FIX interface providing a structural template for understanding the sequential activation of FIX and for developing a new class of selective allosteric antithrombotic agents.

Bassem M Mohammed, Samantha Deavila, Tristan Friet et al. · 0 citations

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