Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors.
EvoMax is established as an integrated strategy for engineering compact eukaryotic Fz2 genome editors and FanzMAX v3-hLa is identified as a high-efficiency programmable nuclease for mammalian genome editing.
Shijie Wan, Jackson Gold, Pranay Vure et al.
· Nature Biotechnology · 0 citations