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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Tracy Fischer

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Open access Apr 2026

Alzheimer’s Disease DNA Methylation Index (AD-DMI) and its Association with Late-Life Cognitive Function

Alzheimer’s disease (AD) is driven by genetic and epigenetic factors. A knowledge gap remains in applying DNA methylation (DNAm) to capture AD-specific signatures. We developed the AD DNA Methylation Index (AD-DMI), a brain-derived risk index constructed from 100 CpG sites identified by elastic-net logistic regression...

N. Jiakponnah, I. Biose, Tracy Fischer et al. · 1 citation

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