The spleen serves as a key site for enhanced erythroid output during anemic stress. While erythroblastic island macrophages are well-established mediators of stress erythropoiesis, the roles of other immune cells remain less defined. Here we show that a specific subset of splenic B cells promotes erythroid recovery u...
Chong Yang, Rui Yokomori, Hui-Chua Lee et al.· Communications Biology· 0 citations
This study identifies P-selectin (Selp) as an evolutionarily conserved surface marker that captures functional and transcriptomic heterogeneity within the elderly hematopoietic stem cell (HSC) compartment.
These findings uncover CAF–bone-marrow cross-talk as a therapeutic target linking stromal inflammation, immune remodeling, and metastatic progression as a therapeutic target linking stromal inflammation, immune remodeling, and metastatic progression.
Yasuto Takeuchi, Hua-Zi Zhang, T. Murayama et al.· bioRxiv· 0 citations
A niche-mimetic culture system that integrates intrinsic and extrinsic bone marrow regulatory cues, including pharmacologic inhibition of the m6A reader YTHDF2 using the small molecule Y13-27, a three-dimensional microenvironment, and N-cadherin-mediated adhesion is established that preserves transcriptional and epigen...
Xinjian Mao, Ning Zhang, Xi C. He et al.· Blood· 0 citations
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