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Toshinobu Seki

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Open access Sep 2026

Evaluation of Histidine–Octamer-Modified Hyaluronic Acid as a Cytosolic Drug Delivery Material via CD44-Mediated Cellular Uptake and Endosomal Escape

His8 modification alters HA intracellular localization while preserving CD44 targeting, thereby facilitating endosomal escape and highlighting HA–His8 as a potential platform for the cytosolic delivery of macromolecular therapeutics, including proteins, peptides, and nucleic acids.

Tomona Yukimura, Hirono Ito, Takahiro Suzuki et al. · 0 citations

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