Toni-Ann J. Yapp

Variant Harmonization Critically Determines Polygenic Score Transferability for Lipid Traits in Samoan Populations.

Dyslipidemia is a significant risk factor for cardiovascular disease (CVD), the leading cause of death in Samoa. Polygenic scores (PGS) for lipid traits offer promise for improved CVD risk prediction; however, their performance in Pacific Islander populations - comprising only 0.002% of GWAS participants as of 2024 - r...