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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Tong-Yu Zhou

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Review Sep 2026

An analytical overview of the ceramide-sphingosine-sphingosine-1-phosphate axis in ischemic stroke: synthesis, metabolic dynamics, and functional conversion.

Ischemic stroke rapidly remodels sphingolipid metabolism across the neurovascular unit. Ceramide, sphingosine, and sphingosine-1-phosphate (S1P) form an interconvertible axis that connects membrane metabolism with mitochondrial dysfunction, endoplasmic reticulum stress, inflammatory signaling, blood-brain barrier integ...

Ming-Yong Xie, Xiao-Yu Shang, Tong-Yu Zhou et al. · 0 citations

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