Author

Tong-Yang Xu

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Open access Sep 2026

Chemically Induced Proximity for Targeted Protein O- GlcNAcylation

O-GlcNAcylation is a ubiquitous post-translational modification across the mammalian proteome, yet determining how individual O-GlcNAcylation events control specific protein functions remains a central challenge. The O-GlcNAc cycle is governed by two enzymes: O-GlcNAc transferase (OGT), which installs O-GlcNAc, and O...

Bo-Wen Ma, Tong-Yang Xu, Zhi-Hao Guo et al. · Accounts of Chemical Researc... · 0 citations

Review Open access Sep 2026

Targeted Control of Protein O-GlcNAcylation in Living Cells.

O-linked N-acetylglucosamine glycosylation (O-GlcNAcylation) regulates many intracellular proteins, but linking a cellular phenotype to O-GlcNAcylation of a specific substrate remains difficult. Global perturbation of O-GlcNAc transferase (OGT) or O-GlcNAcase (OGA) changes many proteins at once and therefore provides l...

Tong-Yang Xu, Billy Wai-Lung Ng · Glycobiology · 0 citations

Sep 2026

Targeted O-GlcNAcylation enables functional rewiring of c-Myc.

An O-GlcNAcylation-targeting Chimera (OGTAC) is developed that recruits O-GlcNAc transferase (OGT) to the oncogenic transcription factor c-Myc, enabling targeted O-GlcNAcylation in living cells without globally perturbing cellular O-GlcNAcylation.

Tong-Yang Xu, Zhi-Hao Guo, K. S. Khan et al. · Cell Chemical Biology · 2 citations