Genetic and Molecular Mechanisms of Synaptic Plasticity in Perioperative Delirium: From Neuroinflammation to Circuit Dysfunction and Recovery
Perioperative delirium is an acute disturbance of attention and awareness that arises when surgical stress interacts with limited brain reserve. Synaptic dysfunction provides a plausible connection between genetic susceptibility, neuroimmune responses and fluctuating network activity, but the strength of evidence diffe...