Tongtong Chen

Hierarchical Phase Transitions in Bayesian Flow Networks Enable Training-Free Molecular Design

Bayesian flow networks (BFNs) jointly model atomic coordinates and atom types for structure-based drug design, but their generative dynamics remain poorly understood. We show that the two channels resolve on different terms: atom types pass through a sharp commitment transition at tc1, whereas coordinate precision im...

[Optical genome mapping analysis of a Chinese pedigree with a complex balanced translocation involving four chromosomes].

Biallelic variants in IBA57 with multiple mitochondrial dysfunction syndrome 3

Background Multiple mitochondrial dysfunction syndrome type 3 (MMDS3; OMIM #615330) is a rare autosomal recessive disorder caused by mutations in IBA57. Its complex clinical presentation and molecular pathogenesis remain incompletely understood. Methods The study included comprehensive clinical evaluation, IBA57 geneti...