Pediatric brain tumors remain the leading cause of cancer-related mortality in children, and disparities in clinical outcomes have been observed across racial and ethnic groups. While socioeconomic and socio-environmental factors contribute to these disparities, the extent to which ancestry-associated tumor biology i...
Jin-Nan Chen, Yi-Ming Mei, Xin Zhai et al.· Cancer Epidemiology, Biomark...· 0 citations
This review systematically illustrates the regulatory networks governing GBM pathogenesis and TMZ resistance, and dissects signaling cascades of distinct resistance mechanisms and crosstalk between core signaling axes, and identifies key regulatory molecules and druggable targets for each resistance phenotype.
Ying Qin, Yu-Fang Zhao, Bo-Wen Li et al.· Biochimica et biophysica act...· 0 citations
A heterogeneity-informed framework for patient stratification and precision immunotherapy development in GBM is proposed, and major translational challenges are highlighted, including blood-brain barrier penetration, cell-type-specific pathway activation, treatment-induced pathway remodeling, and biomarker selection.
Yu-Zhu Long, Tong-Cui Jiang, Yu Long et al.· Biomedicine & pharmacotherap...· 0 citations
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