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Author

Tomomi Kiyomitsu

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Open access Aug 2026

Balanced RCC1 activity organizes the specialized spindle midplane during cleavage divisions

Chromosome-bound RCC1 generates Ran-GTP signals to organize functional spindles for faithful chromosome segregation during mitosis and meiosis. RCC1 is the sole guanine nucleotide exchange factor (GEF) for Ran and is essential for spindle assembly during early, but not late, embryonic divisions. However, how RCC1 organ...

Ming Yang, Ai Kiyomitsu, Yutei Takahashi et al. · 0 citations
Open access Aug 2026

KIFC1 overexpression induces monopolar spindles by preventing centrosome separation during rapid cleavage divisions

Bipolar spindle assembly is essential for accurate chromosome segregation. KIFC1, a conserved Ran- regulated minus-end-directed kinesin-14 motor, accumulates in the nucleus during interphase and promotes chromatin-mediated spindle assembly during mitosis and meiosis. In human oocytes, reduced KIFC1 levels destabilize m...

Takahiro Yamamoto, Ai Kiyomitsu, Ming Yang et al. · 0 citations

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