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Author

Tomoki Kuwahara

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Open access Sep 2026

STING activation drives pericentrosomal positioning of acidic organelles via the VAIL-LRRK2-Rab35 pathway

The cGAS-STING pathway is an innate immune system that responds to cytoplasmic double-stranded DNA, but recent studies have highlighted its noncanonical role in facilitating lysosomal stress responses. Specifically, STING activation has been shown to trigger V-ATPase-ATG16L1-induced LC3 lipidation (VAIL) and to activat...

Shoichi Suenaga, Maria Sakurai, T. Iwatsubo et al. · 0 citations

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