STING activation drives pericentrosomal positioning of acidic organelles via the VAIL-LRRK2-Rab35 pathway
The cGAS-STING pathway is an innate immune system that responds to cytoplasmic double-stranded DNA, but recent studies have highlighted its noncanonical role in facilitating lysosomal stress responses. Specifically, STING activation has been shown to trigger V-ATPase-ATG16L1-induced LC3 lipidation (VAIL) and to activat...